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Shop Best-Selling Oral Care

  • Whitening System

    Whitening System

    Regular price   $81.00 Sale price   $75.00

  • Wellnesse oral care kit featuring toothpaste, floss picks, probiotics, copper tongue scraper, and toothbrush

    Mineralizing Oral Care Kit

    Regular price   $103.00 Sale price   $68.00

  • Wellnesse hydroxyapatite serum fluoride-free tube on a natural wood slice with green foliage backdrop

    Hydroxyapatite Serum

    $60.00

  • Wellnesse natural whitening toothpaste in fresh mint with teal cap on a wood slice with greenery behind

    Whitening Toothpaste

    $15.00

  • Wellnesse vanilla toothpaste in berry flavor standing on a wood slice surrounded by fresh greenery

    Vanilla Berry Toothpaste

    $15.00

  • Wellnesse natural toothpaste for kids in strawberry flavor with a pink tube on a wood slice

    Strawberry Toothpaste

    $15.00

  • Wellnesse cinnamon toothpaste tube with red cap in peppermint and cinnamon flavor on a wood slice

    Cinnamint Toothpaste

    $15.00

  • Wellnesse charcoal toothpaste tube standing on a rustic wood display with fresh greenery in the background

    Charcoal Toothpaste

    $15.00

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10% Hydroxyapatite Fluoride-Free

Hydroxyapatite Serum

$60.00 USD

Real Results. No Toxins. No Compromise.

This isn't your typical oral care product, it's a dental-grade oral care serum for remineralization.

Formulated with micro-hydroxyapatite, soothing botanicals, and microbiome-friendly actives, our Hydroxyapatite Serum delivers next-level care to strengthen enamel, reduce sensitivity, and support total-mouth wellness.

Why You’ll Love It

  • Non-Toxic, Dentist-Grade Protection Powered by 10% micro hydroxyapatite, a clinically studied alternative to fluoride that strengthens enamel and whitens teeth, safely.
  • Reduces Tooth Sensitivity Fast
    Our two-particle HAP system targets both surface enamel and deeper tubules to seal and soothe sensitive teeth.
  • Supports a Healthy Oral Microbiome
    With L-Arginine, Xylitol, and Peppermint Oil, this serum helps create a mouth environment where good bacteria thrive, and bad ones don’t.
  • Whitens Naturally
    Gentle, non-abrasive brightening thanks to Aloe, Sodium Bicarbonate, and hydroxyapatite, no bleaching agents or harsh chemicals.
  • Safe for the Whole Family
    Fluoride-free, toxin-free, and safe enough for kids, this is the daily oral care boost your household can trust.

Micro-Hydroxyapatite (10%)

A natural, bio-identical mineral that remineralizes enamel and reduces sensitivity.

  • 5% over 3 microns: remineralizes surface enamel
  • 5% under 3 microns: enters dentin tubules to seal and soothe.

Xylitol

Helps prevent cavities by inhibiting Streptococcus mutans and encouraging saliva production. Supports a balanced oral pH.

L-Arginine

Helps neutralize acidity and promotes beneficial nitrate-reducing bacteria for microbiome health.

Aloe Vera

Soothes gums, reduces inflammation, and may help reduce staining and gingivitis.

Humic & Fulvic Acids

Detoxifying, antimicrobial compounds that help remove toxins, support healing, and reduce inflammation.

  • Humic: “Nature’s Janitor” – attracts and removes bio-waste and heavy metals.
  • Fulvic: Delivers nutrients into cells and supports detoxification.

Peppermint Oil

Naturally antimicrobial and refreshing, supports fresh breath and a healthy mouth.

Sodium Bicarbonate

Balances pH, gently whitens, and supports healthy bacteria.

Alpha Bisabolol

A powerful, plant-based anti-inflammatory (from chamomile) that supports healing and reduces oral irritation.

PURIFIED WATER, SORBITOL, HYDROXYAPATITE, XYLITOL, XANTHAN GUM, POTASSIUM SORBATE, POTASSIUM CHLORIDE, L-ARGININE, ALOE VERA, STEVIA, PEPPERMINT OIL, SODIUM BICARBONATE, HUMIC ACID, FULVIC ACID, ALPHA BISABOLOL

Brush on, let sit, and rinse.

Apply directly to the teeth using a toothbrush or finger. Let sit for 30 minutes to allow the formula to penetrate and remineralize. Rinse gently with water. Use once daily for best results.

The tube and caps are fully recyclable.

Order within the next 23 hours 11 minutes to receive it. Estimated delivery is between Sunday, 24 May and Tuesday, 26 May.
  • Fluoride-free
  • Glycerin-free
  • Natural micro-hydroxyapatite
  • Remineralizes tooth enamel
  • Sustainably sourced
  • Made in the USA
  • Safe for all ages
  • Trusted by Dentists and B-corp Certified

60 DAY MONEY-BACK GUARANTEE

If you're not happy with your purchase for whatever reason, just contact our customer service team within 60 days and we'll make sure you're happy.

How We Measure Up

Compare our formulation to the competition.

Wellnesse Competitor #1 Competitor #2
Price ✔️ $60 for 1.75 oz ✖️ $125 for 1.36 oz ✖️ $98 for 1.25 oz
Strength ✔️ 10% Active Micro-Hydroxyapatite ✖️ 8.6% Nano-Hydroxyapatite ✖️ 8% Nano-Hydroxyapatite
Quality ✔️ Safe for all ages and daily use ✖️ Nano-hydroxyapatite may pose potential health risks, according to some research. ✖️ Nano-hydroxyapatite may pose potential health risks, according to some research.
Wellnesse hydroxyapatite serum fluoride-free tube on a natural wood slice with green foliage backdrop

Hydroxyapatite Serum

$60.00

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Meet Our NEW Professional-Grade, Remineralizing Serum

Upgrade your oral care routine with our most powerful fluoride-free formula yet.

This daily-use tooth serum features 10% micro hydroxyapatite in two optimized particle sizes to remineralize enamel, reduce sensitivity, and restore your natural whiteness — all while supporting your oral microbiome. It’s like a fluoride varnish… without the fluoride.

Why You’ll Love It

  • Helps relieve sensitivity
  • Strengthens enamel
  • Whitens naturally
  • Neutralizes mouth acidity
  • Promotes healthy bacteria
  • Safe for kids and adults
  • Free from fluoride, SLS, parabens & artificial dyes
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Oral Care Approved by Top Dental Professionals

What Experts Are Saying

  • DR. MEGHAN THOMAS, DMD

    DR. MEGHAN THOMAS, DMD

    "I use Wellnesse toothpaste and recommend it to my patients.

    It contains hydroxyapatite, that helps support tooth enamel to keep teeth strong. Wellnesse toothpaste gets your teeth just as white (if not whiter) than everything else - without all the chemicals. Why would anyone NOT switch?”

  • DR. RYAN PORTER, DDS

    DR. RYAN PORTER, DDS

    "I highly recommend it for all my patients. It's simply much healthier and reparative.

    Wellnesse is amazing! Not only do I use Wellnesse for my personal care, I highly recommend it for all my patients. It's simply much healthier and reparative."

  • CHELSEA PULEO

    CHELSEA PULEO

    "I love their philosophy as well as their clean ingredient list.

    Finding a toothpaste with clean ingredients that actually works has been a challenge for me. When I discovered Wellnesse, I knew it was the right fit for us… I love their philosophy as well as their clean ingredient list!"

4.7
Rated 4.7 out of 5 stars
Based on 1,595 reviews
Total 5 star reviews: 1.3k Total 4 star reviews: 158 Total 3 star reviews: 53 Total 2 star reviews: 18 Total 1 star reviews: 23
94%would recommend these products
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1,595 reviews
  • EC
    Emily C.
    Verified Buyer
    Reviewing
    Whitening Toothpaste
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    Beyond compare

    This toothpaste is beyond compare. Why would I want to shop for any other toothpaste? The people who created this toothpaste are miracle workers. Thank you so much.

  • KR
    Kathy R.
    Verified Buyer
    Reviewing
    Whitening Toothpaste
    I recommend this product
    Rated 5 out of 5 stars
    7 months ago
    Unbelievable

    I cannot below the way this toothpaste cleans coffee stains from my teeth. It is amazing.

  • SE
    Stephanie E.
    Verified Buyer
    Reviewing
    Hydroxyapatite Serum
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Grateful

    A friend turned me onto the Wellnesse products. i’ve been using the toothpaste for a while and really like it. When they came out with this product, I wanted to try it. At first it looked like it was kind of pricey for what it was. But I read the information on the website and realized that this is micro hydroxyapatite not nano. Big difference! So I’m grateful to find a clean version! No more cavities or hypersensitivity!

  • J
    Jacob
    Verified Buyer
    Reviewing
    Whitening Toothpaste
    I recommend this product
    Rated 4 out of 5 stars
    2 months ago
    Good toothpaste. Overpriced.

    I’ve been a return customer for a while, this toothpaste seems to work well. I’m tired of paying $15 for a tube of toothpaste that is brand new, and it coming half full. Just put the toothpaste in the smaller tubes. If people realized the amount of toothpaste they were getting for $15 plus shipping, I don’t think they would sell as much. Here’s a picture of a brand new tube unused and you can see it is barely half full.

    W Profile picture for Wellnesse
    Wellnesse
    2 months ago

    Thanks for your feedback! All of our tubes are made from sugarcane, a bioplastic with a negative carbon footprint during production. This flexible bioplastic, combined with the sodium bicarbonate in the formula, allows the tubes to expand slightly in transit, which can make them look less full. Each tube contains exactly 4 ounces. We apologize for any inconvenience.

  • LM
    LuAnn M.
    Verified Buyer
    Reviewing
    Hydroxyapatite Serum
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    It works!

    I have had sensitive teeth due to grinding over the years and decided to try the serum. I had been using hydroxyapatite toothpaste for a couple weeks already. The serum IS WONDERFUL. I am so grateful it works! No more sensitivity 💓

Your Cart

"I am so grateful to have found this healthy alternative and my whole family is now using it and loving it!! Thank you Wellnesse!"

- Michele K.

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Shop Best-Selling Oral Care

  • Whitening System

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  • Mineralizing Oral Care Kit

    Regular price   $103.00 Sale price   $68.00

  • Hydroxyapatite Serum

    $60.00

  • Whitening Toothpaste

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  • Strawberry Toothpaste

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